Mathematical Biology and Medicine

Jobs News
Current and forthcoming programs, conferences and workshops

Some recent papers of interest
- Pre-existing humoral immunity to human common cold coronaviruses negatively impacts the protective SARS-CoV-2 antibody response
- A stochastic intracellular model of anthrax infection with spore germination heterogeneity
- Diffusion in a Disk with a Circular Inclusion codes and figures
- Competitive binding of STATs to receptor phospho-Tyr motifs accounts for altered cytokine responses
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COVID-19 and non-traditional mask use: How do various materials compare in reducing the infection risk for mask wearers?
- Collective
decision-making by rational agents with differing preferences
- The dynamics of stem and crown groups
- Bacterial transfer to fingertips during sequential surface contacts with and without gloves
- Stochastic dynamics of Francisella tularensis infection and replication
- Multiscale modelling of bacterial infections

Eco-Evolutionary Dynamics of Fluctuating Populations
QuanTII




Recent seminars
- 24 Feb 2022
Lea Sta (Leeds)
Mathematical modelling of a receptor-ligand system MoRN seminar - Thu 30 July 2020
Marc Jenkins (Minnesota)
CD4+ T cell differentiation during infection
Abstract: This talk will describe how naive CD4+ T cells differentiate into Th1 or follicular helper T cells during different infections. A two-step model of Th1 differentiation will be described. - Audrey Gerard (Oxford)
CD8 T cell collective behaviour in health and disease
Wed 11 Dec 2019
CD8 T cell responses are key to eradicate virus, intracellular bacteria and cancer cells. A crucial feature of this response is to recruit T cells that will kill pathogen-infected cells or tumour cells while sparing healthy tissues. A multitude of CD8 T cell clones are recruited during an immune response, each with distinct T cell antigen receptors (TCR) with different affinity for their antigen. This clonal breadth is consistently observed despite factors favouring dominance of one or a few clones. How and why this diversity exists is unclear. Our central hypothesis is that T cells integrate individual responses into a collective response through direct communication to preserve T cell clonal breadth. We propose that T cells behave collectively in part through direct co-regulation through cytokines, allowing for lower-affinity clones to emerge and survive despite the competitive environment. I will discuss the consequences of direct T cell communication through the cytokine IFNγ on anti-bacterial responses, and how it impedes anti-tumour responses. -
Oscar Rodriguez de Rivera Ortega (Kent)
Spatial and spatio-temporal models to understand ecological processes
Wed 23rd Oct 2019, 12:00-13:00 -
Systems Pharmacology and Pharmacometrics: How Mathematics, Statistics and Data Science Are Impacting Drug Discovery and Development
Paolo Vicini (Kymab Ltd)
18 Oct 2019 13.30
Modern drug discovery and development are rapidly becoming more reliant on rigorously quantitative approaches. In addition to established statistical testing and experimental design techniques, new approaches include pharmacometrics and systems pharmacology. Pharmacometrics is a collection of quantitative tools applied to clinical drug development and trial design, including mixed effect models for drug exposure and response, and covariate selection methods to quantify the impact of demographic, disease status and genetic variation on drug dosing, concentration and effect. Systems pharmacology is an evolution of systems biology, which seeks to harness quantitative, time-dependent pathway models to predict and quantify the effects of pharmacological interventions on downstream biomarkers, ultimately aiding rationalize target and drug candidate selection. This presentation will describe modern drug discovery and development pipelines and the role of pharmacometrics and systems pharmacology, highlighting in particular their interdisciplinary nature and the extent to which they borrow from other discipline, including mathematics, statistics and computer science.
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Damian Clancy (Heriot-Watt University, UK)
Approximating persistence time for SIS infections in heterogeneous populations
Wed 9th Oct 2019, 12:00-13:00 -
Prof. Uwe C Tauber (Department of Physics, Virginia Tech, USA)
Stochastic Spatial Predator-Prey Models
Wednesday 2nd Oct 2019, 12:00-13:00 -
A mathematical adventure in immunology Carmen Molina-París
International Centre for Theoretical Sciences, Bangalore. 7 Jul 2019 - Thursday 23rd May
Dr Maria Nowicka (Department of Pathology and Cell Biology, Columbia University, US)
Differential impact of self and environmental antigens on the ontogeny and maintenance of CD4+ T cell memory
Laboratory mice not exposed to overt infections nevertheless develop populations of circulating memory phenotype (MP) CD4+ T cells, presumably in response to environmental, commensal or self-antigens. The relative importance and timing of the forces that generate these populations remain unclear. We combine mathematical models with data from studies tracking the generation of CD4+ MP T cell subsets in mice of different ages, housed in facilities that differ in their `dirtiness'. We infer that both central and effector CD4+ MP T cell populations derive directly from naive CD4 T cells, and are heterogeneous in their rates of turnover. We also infer that early exposure to self and environmental antigens establishes persistent memory populations at levels determined largely, but not exclusively, by the dirtiness of the environment. After the first few weeks of life, however, these populations are continuously supplemented by new memory cells at rates that appear to be independent of environment, likely in response to self or ubiquitous commensal antigens.
Recent visitors




- Joe Gillard and Tom Laws
-
Mario Castro works on mathematical models of systems where
fluctuations are relevant (cellular and receptor immunology) and on
pattern formation in spatially extended systems (from tumour cell
modelling to cauliflower morphogenesis or nano-structuring). The figure
shows comparisons of different mathematical models with real
experiments.
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Recent programs, conferences and workshops
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- Sensing and Signaling in Immune Systems: Mathematics meets Biology BIRS Banff, Feb 2022
- NEPA 2020-21
- PiNEJan2021
- PiNE 10-14 Sep 2020
- Society for mathematical biology 17-20 Aug 2020
- British Early Career Mathematicians' Colloquium (virtual colloquium) 14-15 Jul 2020
- Mathematical and Computational Biomedicine Oaxaca. 3-8 Nov 2019
- Cancer and Inflammation: From Micro to Macro NIH. 17-18 Oct 2019
- Viral dynamics Paris, France. 21-23 Oct 2019.
- The mathematics of biology and medicine Leeds. 30 Sep 2019
- Numerical analysis and applied mathematics Rhodes, Greece. 23-28 Sep 2019.
- Stochastic modelling in Health and Disease Leeds. 11-13 Sep 2019
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50 Years of Stochastic Processes at UCSD: a symposium in honor of Katja Lindenberg
15-16 Aug 2019.
- Immunology of human diseases Santa Fe, NM. 28-31 Jul 2019.
- Society for Mathematical Biology annual conference Montréal. 21-26 Jul 2019
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Fluctuations, tipping points and emergence in eco-evolutionary dynamics
Leeds. 2-5 Jul 2019
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Mathematical and Statistical Explorations in Disease Modelling and Public Health
Bangalore, India. 1-11 Jul 2019
- Mathematical and statistical challenges in viral dynamic models: Ebola virus as a paradigm ICMS Edinburgh. 10-28 Jun 2019
- Systems Biology of Human Disease Berlin, Germany. 27-29 May
- Mathematical modelling in immunology Cambridge, 9-10 May 2019.
- Systems Immunology Cold Spring Harbour, 13-16 Mar 2019.
- T-cell memory: thinking outside the blood Trippenhuis KNAW, Amsterdam. 28-30 Nov2018
- Stochasticity and Control in the Dynamics and Diversity of Immune Repertoires Institut des Systèmes Complexes, Paris. 28-31 Oct 2018
- Advanced asymptotics of PDEs, modeling and extreme statistics and their applications to data analysis in cell biology Pisa, 15 September - 31 Oct 2018
- Frontiers in Basic Immunology NIH, Bethesda, MD 27-28 Sep 2018
- Systems Biology London, 3-4 Sep 2018
- PiNE Durham, 12 Sep 2018
- Synthetic immunity Santa Fe, NM. 10-14 Jul 2018
- Quantitative Analysis of Immune Cell Migration and Spatial Processes in Health and Disease BIRS Oaxaca, 24-29 Jun 2018
- British Society for Immunology: Mathematical Modelling affinity group meeting Cambridge, 7-8 Jun 2018.
- Systems immunology Surrey, 27-28 Mar 2018.
- Host-pathogen dynamics Ohio, 19-23 Feb 2018
- PiNE Leeds, 16 Feb 2018
- Modelling infectious diseases in the cell and host Singapore, 22-24 Jan 2018.
- Quantitative Principles in Biology at EBML Heidelberg, 2-4 Nov 2017
- Systems out of equilibrium Warwick. 27 Nov 2017
- Synthetic Immunity Santa Fe, NM. 10-14 Jul 2017.
- Network Dynamics and Structure Leeds, 25 Jul 2017.
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Climate Fluctuations and Non-equilibrium Statistical Mechanics: An Interdisciplinary Dialogue
10 Jul to 4 Aug at the MPIPKS in Dresden, Germany. -
Biostatistics and machine learning methods in omics research
The 34th Leeds Annual Statistical Research Workshop, joint with the EU MIMOmics network.
Leeds, Monday 26 - Wednesday 28 Jun 2017. - CoSyDy 26 Jun 2017 at Imperial College London.
- Theoretical and Experimental Immunology hosted by Microsoft Research Cambridge, 8-9 Jun 2017.
- Viral Dynamics: Past, Present and Future 5-7 May 2017 in Santa Fe, NM
- Modeling Viral Infections and Immunity 1-4 May 2017
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QuanTI closing meeting 19-21 Apr 2017
- Probability in the North-East
University of Leeds, Thursday 27th Apr 2017
Programme- 10.00 - 10.30 Welcome and Coffee
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10.30 - 11.20 Corina Constantinescu (University of Liverpool)
Ruin probabilities in insurance models -
11.20 - 12.10 Ronnie Loeffen (University of Manchester)
Spectral representations for affine processes - 12.10 - 13.10 Lunch
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13.10 - 14.00 Vicky Henderson (University of Warwick)
Probability weighting, stop-loss and the disposition effect -
14.00 - 14.50 Adrian Pratt (Public Health England)
Back-calculation techniques and other models to inform mitigation strategies of non-transmissible acute infections - 14.50 - 15.20 Coffee Break
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15.20 - 16.10 Theodore Kypraios (University of Nottingham)
Recent developments in Bayesian non-parametric inference for epidemic models -
16.10 - 17.00 Antonio Gómez-Corral (Complutense University of Madrid, Spain)
On perturbation analysis of quasi-birth-death processes with applications to multi-type epidemic models
- Quantitative T cell Immunology Symposium
Hosted by AstraZeneca, Cancer Research UK Cambridge Institute, 21-22 Sep 2016
Wednesday 21st September- 14:35 Ton Schumacher, Netherlands Cancer Institute
T cell recognition and tumor resistance in human cancer - 15:35 Simon Dovedi Medimmune
Modelling the immunobiology of radiotherapy in cancer - 16:00
Ken Duffy, Hamilton Institute NUI Maynooth
T cell signal integration and an algebra of tree concatenation
- 09:30 Melania Barile, German Cancer Research Centre, Heidelberg
Quantifying the flux through haematopoiesis - 10:00 Sarah Teichmann, Wellcome Trust Sanger Institute
Understanding cellular heterogeneity - 11:10 Cathal Seoighe, NUI Galway
Promiscuous mRNA splicing under the control of AIRE in medullary thymic epithelial cells - 12:00 Mariona Baliu Piqué, UMC Utrecht
Is long-lasting memory provided by short-lived cells? A closer look at CD8+ memory T cell dynamics
- Lessons to be learnt from mathematical models of T cells University of Glasgow, 17 Nov, 2016.
- Robustness, Adaptability and Critical Transitions in Living Systems
Amsterdam, The Netherlands. 19-22 Sep 2016- Systems Immunology Santa Fe. 27-28 Sep 2016.
- International Congress of Immunology Melbourne 21-26 Aug 2016
- Mathematical and Systems Immunology session at ECMTB Nottingham, 11-15 Jul 2016.
- Stochastic Dynamical Systems in Biology: Numerical Methods and Applications
Isaac Newton Institute, Cambridge. Jan-Jun 2016- Theoretical and experimental immunology Cambridge. 16-17 June 2016
- Big Data Analytics at Leeds
Wednesday 11 May 2016.- Be curious 19 Mar 2016
- Spring school on lymphocyte dynamics Unilever. 17-18 Mar 2016
- Single-cell biology EBI Hinxton. 8-10 Mar 2016
- Quantitative Immunology KITP Santa Barbara. 1-19 Feb 2016
- PiNE Probability in the North-East
Friday 6 November 2015
Complex stochastic systems arising in applications and interdisciplinary research
School of Mathematics, University of Leeds. Room: MALL 1
Programme 2015 - 13.30 -- 14.20 Carmen Molina-París (University of Leeds)
Stochastic modelling of T cell receptor clonotype competition - 14.20 -- 15.10 Malwina Luczak (Queen Mary, University of London)
SIR epidemics on random graphs with a given degree sequence - 15.30 -- 16.20 Anton Camacho (London School of Hygiene and Tropical Medicine)
The impact of dynamical modelling on public-health decisions made during the 2013-2015 Ebola outbreak - 16.20 -- 17.10 Alexandre Veretennikov (University of Leeds)
On convergence in Erlang-Sevastyanov queueing systems and in reliability theory
- Numerical Modeling in Evolutionary Problems: perspectives and applications Salerno, 26-27 Nov 2015
- Workshop on Physics of Living Systems San Servolo island, Venice, Italy. 16-19 September, 2015
- Stochastic Single-Cell Dynamics in Immunology Amsterdam, 17-19 June 2015
- British Society for Immunology: Mathematical Modelling Microsoft Research Cambridge. 4-5 Jun 2015
- Mathematics for health and disease ICMS Edinburgh. 13-17 Apr 2015
- LIVING -- Robustness, adaptability and critical transition in living systems
Satellite conference at the annual European Conference on Complex Systems (ECCS14)- Stochastic modelling and immunology Ecology, Evolution and Dynamics of Dengue and other Related Diseases Arizona, 4-5 Aug 2014
- BSI Mathematical Modelling, Microsoft Research Cambridge, 19-20 May 2014.
- Novel Applications of Statistical Mechanics Boston, 10-11 may 2014
- Dynamics of Active Matter Imperial College London, Wednesday 7th May .
- Quantitative immunology Les Houches, France. 9-14 Mar 2014
- Systems Approaches in Immunology Santa Fe, USA. 10-11 Jan 2014
- Mathematical modelling affinity group session at the BSI congress 2013
- Modelling the Complexity of the Immune System Barcelona, 16-20 September 2013.
- Stochastic, statistical and computational approaches to Immunology
International Centre for Mathematical Sciences, Edinburgh. 22-26 Jul 2013- Complexity Systems Dynamics Leeds, 5 June 2013.
- Mathematical and computational modelling in immunology
Cambridge, 8-9 May 2013.- Simulation Models of Infectious Disease Transmission and Control Processes
Antwerp, 17-18 Apr- BAMC 2013
- Systems biology of T cells Baeza, Spain. 21-24 Oct 2012
- Multiscale physics of lymphocyte development
Max Planck Institute for the Physics of Complex Systems,
Dresden, Germany. 5-31 Aug 2012- New Statistics and Modern Natural Sciences Leeds, 3-5 Jul 2012
- Theoretical and experimental immunology 25-26 Jun 2012 poster
- Synchronisation in Complex Systems 11 May, London.
- Computational Immunology
WEHI Melbourne, 11-13 Apr 2012- Evolution and diversity in complex systems Leeds, 2 Mar 2012.
- Theoretical and Experimental Immunology IISc Bangalore, 16 Aug 2011 Abstracts
- Theoretical immunology network meeting on 16 May 2011 at the University of Leeds
- Imaging, Interpretation and Modeling in Modern Immunology Banff, 10-15 Apr 2011
- Physics of Immunity: Complexity Approach 4-8 Apr 2011, Max-Planck-Institut Dresden
- Experimental and theoretical immunology on 18 Mar 2011 at the University of Leeds
- Experimental and theoretical immunology in the real world at the University of Leeds 10 Jan 2011.
- Yorkshire Immunology Group "Pattern recognition receptors in the immune system" 24 Nov 2010, Leeds Institute of Molecular Medicine, University of Leeds
- Movement in Models of Mathematical Biology 15 November 2010, University of Warwick
- Stochastic dynamics and applications Monday 18 October 2010, University of Leeds
- Immunology, Imaging and Modelling Network Summer School at the University of Leeds 13-17 September 2010.
- High-throughput Sequencing, Proteins and Statistics (29th Leeds Annual Statistical Research Workshop) 6th-8th Jul 2010
- Probability in the North-East