Mathematical Biology and Medicine


Current and forthcoming programs, conferences and workshops
- Mathematical Life Sciences Bonn, 17-20 Apr 2023
- Dynamics & Evolution of Human Viruses Heidelberg, 19-22 Apr 2023
- QuanTII closing meeting, 8 May 2023
- BSI mathematical modelling affinity group meeting, 15 May 2023
Seminars
9 March, 12:00-13:00MALL, School of Mathematics Felicia Magpantay (Queen's University)
Challenges in modeling the transmission dynamics of childhood diseases
Abstract: Mathematical models of childhood diseases are often fitted using deterministic methods under the assumption of homogeneous contact rates within populations. Such models can provide good agreement with data in the absence of significant changes in population demography or transmission, such as in the case of pre-vaccine era measles. However, accurate modeling and forecasting after the start of mass vaccination has proved more challenging. This is true even in the case of measles which has a well understood natural history and a very effective vaccine. We demonstrate how the dynamics of homogeneous and age-structured models can be similar in the absence of vaccination, but diverge after vaccine roll-out. We also present some fundamental differences in deterministic and stochastic methods to fit models to data, and propose techniques to fit long term time series with imperfect covariate information. The methods we develop can be applied to many types of complex systems beyond those in disease ecology.
Recent theses
Bevelynn Williams Mechanistic intracellular and within-host models of bacterial and viral infections ![]() Feb 2023 |
Giulia Belluccini Stochastic models of cell population dynamics and tick-borne virus transmission ![]() Feb 2023 |
Polly-Anne Jeffrey Mathematical Modelling of Cellular Receptor-Ligand Dynamics ![]() Oct 2021 |
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Recent programs, conferences and workshops
ECMTB 2022 Immunoctoberfest 2022![]() |
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- Sensing and Signaling in Immune Systems: Mathematics meets Biology BIRS Banff, Feb 2022
- NEPA 2020-21
- PiNEJan2021
- PiNE 10-14 Sep 2020
- Society for mathematical biology 17-20 Aug 2020
- British Early Career Mathematicians' Colloquium (virtual colloquium) 14-15 Jul 2020
- Mathematical and Computational Biomedicine Oaxaca. 3-8 Nov 2019
- Cancer and Inflammation: From Micro to Macro NIH. 17-18 Oct 2019
- Viral dynamics Paris, France. 21-23 Oct 2019.
- The mathematics of biology and medicine Leeds. 30 Sep 2019
- Numerical analysis and applied mathematics Rhodes, Greece. 23-28 Sep 2019.
- Stochastic modelling in Health and Disease Leeds. 11-13 Sep 2019
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50 Years of Stochastic Processes at UCSD: a symposium in honor of Katja Lindenberg
15-16 Aug 2019.
- Immunology of human diseases Santa Fe, NM. 28-31 Jul 2019.
- Society for Mathematical Biology annual conference Montréal. 21-26 Jul 2019
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Fluctuations, tipping points and emergence in eco-evolutionary dynamics
Leeds. 2-5 Jul 2019
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Mathematical and Statistical Explorations in Disease Modelling and Public Health
Bangalore, India. 1-11 Jul 2019
- Mathematical and statistical challenges in viral dynamic models: Ebola virus as a paradigm ICMS Edinburgh. 10-28 Jun 2019
- Systems Biology of Human Disease Berlin, Germany. 27-29 May
- Mathematical modelling in immunology Cambridge, 9-10 May 2019.
- Systems Immunology Cold Spring Harbour, 13-16 Mar 2019.
- T-cell memory: thinking outside the blood Trippenhuis KNAW, Amsterdam. 28-30 Nov2018
- Stochasticity and Control in the Dynamics and Diversity of Immune Repertoires Institut des Systèmes Complexes, Paris. 28-31 Oct 2018
- Advanced asymptotics of PDEs, modeling and extreme statistics and their applications to data analysis in cell biology Pisa, 15 September - 31 Oct 2018
- Frontiers in Basic Immunology NIH, Bethesda, MD 27-28 Sep 2018
- Systems Biology London, 3-4 Sep 2018
- PiNE Durham, 12 Sep 2018
- Synthetic immunity Santa Fe, NM. 10-14 Jul 2018
- Quantitative Analysis of Immune Cell Migration and Spatial Processes in Health and Disease BIRS Oaxaca, 24-29 Jun 2018
- British Society for Immunology: Mathematical Modelling affinity group meeting Cambridge, 7-8 Jun 2018.
- Systems immunology Surrey, 27-28 Mar 2018.
- Host-pathogen dynamics Ohio, 19-23 Feb 2018
- PiNE Leeds, 16 Feb 2018
- Modelling infectious diseases in the cell and host Singapore, 22-24 Jan 2018.
- Quantitative Principles in Biology at EBML Heidelberg, 2-4 Nov 2017
- Systems out of equilibrium Warwick. 27 Nov 2017
- Synthetic Immunity Santa Fe, NM. 10-14 Jul 2017.
- Network Dynamics and Structure Leeds, 25 Jul 2017.
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Climate Fluctuations and Non-equilibrium Statistical Mechanics: An Interdisciplinary Dialogue
10 Jul to 4 Aug at the MPIPKS in Dresden, Germany. -
Biostatistics and machine learning methods in omics research
The 34th Leeds Annual Statistical Research Workshop, joint with the EU MIMOmics network.
Leeds, Monday 26 - Wednesday 28 Jun 2017. - CoSyDy 26 Jun 2017 at Imperial College London.
- Theoretical and Experimental Immunology hosted by Microsoft Research Cambridge, 8-9 Jun 2017.
- Viral Dynamics: Past, Present and Future 5-7 May 2017 in Santa Fe, NM
- Modeling Viral Infections and Immunity 1-4 May 2017
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QuanTI closing meeting 19-21 Apr 2017
- Probability in the North-East
University of Leeds, Thursday 27th Apr 2017
Programme- 10.00 - 10.30 Welcome and Coffee
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10.30 - 11.20 Corina Constantinescu (University of Liverpool)
Ruin probabilities in insurance models -
11.20 - 12.10 Ronnie Loeffen (University of Manchester)
Spectral representations for affine processes - 12.10 - 13.10 Lunch
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13.10 - 14.00 Vicky Henderson (University of Warwick)
Probability weighting, stop-loss and the disposition effect -
14.00 - 14.50 Adrian Pratt (Public Health England)
Back-calculation techniques and other models to inform mitigation strategies of non-transmissible acute infections - 14.50 - 15.20 Coffee Break
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15.20 - 16.10 Theodore Kypraios (University of Nottingham)
Recent developments in Bayesian non-parametric inference for epidemic models -
16.10 - 17.00 Antonio Gómez-Corral (Complutense University of Madrid, Spain)
On perturbation analysis of quasi-birth-death processes with applications to multi-type epidemic models
- Quantitative T cell Immunology Symposium
Hosted by AstraZeneca, Cancer Research UK Cambridge Institute, 21-22 Sep 2016
Wednesday 21st September- 14:35 Ton Schumacher, Netherlands Cancer Institute
T cell recognition and tumor resistance in human cancer - 15:35 Simon Dovedi Medimmune
Modelling the immunobiology of radiotherapy in cancer - 16:00
Ken Duffy, Hamilton Institute NUI Maynooth
T cell signal integration and an algebra of tree concatenation
- 09:30 Melania Barile, German Cancer Research Centre, Heidelberg
Quantifying the flux through haematopoiesis - 10:00 Sarah Teichmann, Wellcome Trust Sanger Institute
Understanding cellular heterogeneity - 11:10 Cathal Seoighe, NUI Galway
Promiscuous mRNA splicing under the control of AIRE in medullary thymic epithelial cells - 12:00 Mariona Baliu Piqué, UMC Utrecht
Is long-lasting memory provided by short-lived cells? A closer look at CD8+ memory T cell dynamics
- Lessons to be learnt from mathematical models of T cells University of Glasgow, 17 Nov, 2016.
- Robustness, Adaptability and Critical Transitions in Living Systems
Amsterdam, The Netherlands. 19-22 Sep 2016- Systems Immunology Santa Fe. 27-28 Sep 2016.
- International Congress of Immunology Melbourne 21-26 Aug 2016
- Mathematical and Systems Immunology session at ECMTB Nottingham, 11-15 Jul 2016.
- Stochastic Dynamical Systems in Biology: Numerical Methods and Applications
Isaac Newton Institute, Cambridge. Jan-Jun 2016- Theoretical and experimental immunology Cambridge. 16-17 June 2016
- Big Data Analytics at Leeds
Wednesday 11 May 2016.- Be curious 19 Mar 2016
- Spring school on lymphocyte dynamics Unilever. 17-18 Mar 2016
- Single-cell biology EBI Hinxton. 8-10 Mar 2016
- Quantitative Immunology KITP Santa Barbara. 1-19 Feb 2016
- PiNE Probability in the North-East
Friday 6 November 2015
Complex stochastic systems arising in applications and interdisciplinary research
School of Mathematics, University of Leeds. Room: MALL 1
Programme 2015 - 13.30 -- 14.20 Carmen Molina-París (University of Leeds)
Stochastic modelling of T cell receptor clonotype competition - 14.20 -- 15.10 Malwina Luczak (Queen Mary, University of London)
SIR epidemics on random graphs with a given degree sequence - 15.30 -- 16.20 Anton Camacho (London School of Hygiene and Tropical Medicine)
The impact of dynamical modelling on public-health decisions made during the 2013-2015 Ebola outbreak - 16.20 -- 17.10 Alexandre Veretennikov (University of Leeds)
On convergence in Erlang-Sevastyanov queueing systems and in reliability theory
- Numerical Modeling in Evolutionary Problems: perspectives and applications Salerno, 26-27 Nov 2015
- Workshop on Physics of Living Systems San Servolo island, Venice, Italy. 16-19 September, 2015
- Stochastic Single-Cell Dynamics in Immunology Amsterdam, 17-19 June 2015
- British Society for Immunology: Mathematical Modelling Microsoft Research Cambridge. 4-5 Jun 2015
- Mathematics for health and disease ICMS Edinburgh. 13-17 Apr 2015
- LIVING -- Robustness, adaptability and critical transition in living systems
Satellite conference at the annual European Conference on Complex Systems (ECCS14)- Stochastic modelling and immunology Ecology, Evolution and Dynamics of Dengue and other Related Diseases Arizona, 4-5 Aug 2014
- BSI Mathematical Modelling, Microsoft Research Cambridge, 19-20 May 2014.
- Novel Applications of Statistical Mechanics Boston, 10-11 may 2014
- Dynamics of Active Matter Imperial College London, Wednesday 7th May .
- Quantitative immunology Les Houches, France. 9-14 Mar 2014
- Systems Approaches in Immunology Santa Fe, USA. 10-11 Jan 2014
- Mathematical modelling affinity group session at the BSI congress 2013
- Modelling the Complexity of the Immune System Barcelona, 16-20 September 2013.
- Stochastic, statistical and computational approaches to Immunology
International Centre for Mathematical Sciences, Edinburgh. 22-26 Jul 2013- Complexity Systems Dynamics Leeds, 5 June 2013.
- Mathematical and computational modelling in immunology
Cambridge, 8-9 May 2013.- Simulation Models of Infectious Disease Transmission and Control Processes
Antwerp, 17-18 Apr- BAMC 2013
- Systems biology of T cells Baeza, Spain. 21-24 Oct 2012
- Multiscale physics of lymphocyte development
Max Planck Institute for the Physics of Complex Systems,
Dresden, Germany. 5-31 Aug 2012- New Statistics and Modern Natural Sciences Leeds, 3-5 Jul 2012
- Theoretical and experimental immunology 25-26 Jun 2012 poster
- Synchronisation in Complex Systems 11 May, London.
- Computational Immunology
WEHI Melbourne, 11-13 Apr 2012- Evolution and diversity in complex systems Leeds, 2 Mar 2012.
- Theoretical and Experimental Immunology IISc Bangalore, 16 Aug 2011 Abstracts
- Theoretical immunology network meeting on 16 May 2011 at the University of Leeds
- Imaging, Interpretation and Modeling in Modern Immunology Banff, 10-15 Apr 2011
- Physics of Immunity: Complexity Approach 4-8 Apr 2011, Max-Planck-Institut Dresden
- Experimental and theoretical immunology on 18 Mar 2011 at the University of Leeds
- Experimental and theoretical immunology in the real world at the University of Leeds 10 Jan 2011.
- Yorkshire Immunology Group "Pattern recognition receptors in the immune system" 24 Nov 2010, Leeds Institute of Molecular Medicine, University of Leeds
- Movement in Models of Mathematical Biology 15 November 2010, University of Warwick
- Stochastic dynamics and applications Monday 18 October 2010, University of Leeds
- Immunology, Imaging and Modelling Network Summer School at the University of Leeds 13-17 September 2010.
- High-throughput Sequencing, Proteins and Statistics (29th Leeds Annual Statistical Research Workshop) 6th-8th Jul 2010
- Probability in the North-East