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Sary El Daker

Sary El Daker

Experienced Researcher / Post-doc

Institut Pasteur, France
Lymphocyte Population Biology

June 2013 - June 2015

Biography

After an initial training at the "department of Immuno-Mediated Infectious Diseases" (MIPI) of Istituto Superiore di Sanita (ISS) in Rome, where he learned the basics of scientific research (through HIV-1 study), Sary started his PhD course in "Immunology and Applied Biotechnology" at the University of Rome "Tor Vergata". During this time, he acquired experience about innate immunity and tuberculosis, performing studies on the role of gamma delta T cells and Myeloid Derived Suppressor Cells (MDSC) during mycobacterium infection. Then he moved to the laboratory of Gennaro De Libero at the Singapore Immunology Network (SigN) in Singapore, where he has improved his knowledge on T cells activation and his skill in cell cultures, animal handling, flow cytometry. Now  he is working in the laboratories of Antonio Freitas where he is studing the homeostasis of IL-2 producing CD4 T cells and their role in the control of Treg cell function and number.

QuanTI research project

Homeostasis of IL-2 producing CD4 T cells and their role in the control of Treg cell function and number

The immune system is regulated by complex interactions between different cells subsets. Recently, the role of a subpopulation of regulatory CD4+ T cells has been emphasized in the control of T cell homeostasis, immune responses to cancer and auto-immune diseases. We have shown that the number of these Treg cells is strictly controlled and directly related to the number of IL-2 producing T cells. It is therefore likely that control of Treg cell function may be achieved by controlling the number of IL-2 producing cells. In this project we propose to study the homeostasis of IL-2 producing T cells and their role in the induction and control of the number of CD4+CD25+Foxp3+ regulatory T cells. For this purpose we will:

  1. Study the homeostasis of the IL-2 producing T cells in steady state and during homeostatic restoration.
  2. Correlate the numbers of IL-2 producing and Treg cells in existing and new mutant mouse models.
  3. Correlate the numbers of IL-2 producing and Treg cells during immune responses and during tumor development.

With this project, we expect to increase our knowledge of the role of regulatory CD4 T cells in the control of T cell homeostasis, immune responses and auto-immune diseases. By understanding the development and interactions of these regulatory CD4 T cells with other cell populations, in particular with the IL-2 producing T cells, we expect to be able to intervene in several different aspects of the immune system. These studies may allow the development of new strategies using the balance between regulatory and IL-2 producing CD4 T cells to modify T cell homeostasis and treat inflammatory autoimmune diseases and neoplastic diseases. The project will therefore contribute to improve the health aspects of the community.

Supervisors

Prof. Dr. Antonio Freitas, M.D., Ph.D. Head of the Population Biology Unit Director of the CNRS URA 1961 Institut Pasteur tel: +33145688582 fax:+33145688921 antonio.freitas@pasteur.fr

Publications

Butyrophilin 3A1 binds phosphorylated antigens and stimulates human γδ T cells. Vavassori S, Kumar A, Wan GS, Ramanjaneyulu GS, Cavallari M, El Daker S, Beddoe T, Theodossis A, Williams NK, Gostick E, Price DA, Soudamini DU, Voon KK, Olivo M, Rossjohn J, Mori L, De Libero G. Nat Immunol. 2013 Sep;14(9):908-16;

An abnormal phenotype of lung Vγ9Vδ2 T cells impairs their responsiveness in tuberculosis patients. El Daker S, Sacchi A, Montesano C, Altieri AM, Galluccio G, Colizzi V, Martini F, Martino A. Cell Immunol. 2013 Apr;282(2):106-12;

γδ T cells cross-link innate and adaptive immunity in Mycobacterium tuberculosis infection. Meraviglia S, El Daker S, Dieli F, Martini F, Martino A. Clin Dev Immunol. 2011;2011:587315;

"Shock and kill" effects of class I-selective histone deacetylase inhibitors in combination with the glutathione synthesis inhibitor buthionine sulfoximine in cell line models for HIV-1 quiescence. Savarino A, Mai A, Norelli S, El Daker S, Valente S, Rotili D, Altucci L, Palamara AT, Garaci E. Retrovirology. 2009 Jun 2;6:52;

Evaluation of the antiretroviral effects of a PEG-conjugated peptide derived from human CD38. Bensi T, Mele F, Ferretti M, Norelli S, El Daker S, Chiocchetti A, Maria Rojo J, Cauda R, Savarino A. Expert Opin Ther Targets. 2009 Feb;13(2):141-52;

Response of feline immunodeficiency virus (FIV) to tipranavir may provide new clues for development of broad-based inhibitors of retroviral proteases acting on drug-resistant HIV-1. Norelli S, El Daker S, D'Ostilio D, Mele F, Mancini F, Taglia F, Ruggieri A, Ciccozzi M, Cauda R, Ciervo A, Barreca ML, Pistello M, Bendinelli M, Savarino A.
Curr HIV Res. 2008 Jun;6(4):306-17.

 




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Universidade de Vigo

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Last update: 11 June 2017