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Saikrishna Gadhamsetty

Dr. Saikrishna Gadhamsetty

Experienced Researcher / Post-doc

Bayer AG
BTS-TD-ET-SPO
Leverkusen, Germany

email: sai.gadhamsetty @ bayer.com;
skgadhamsetty @ gmail.com


Short biography

I carried out my PhD research in the group of Prof. Rob de Boer, Theoretical Biology and Bioinformatics, Utrecht University, Netherlands, and I defended my PhD thesis in October 2015.

Prior to my PhD, I received my masters and bachelor degrees in Chemical Engineering, respectively, from Indian Institute of Science, Bangalore, India; and Osmania University, Hyderabad, India.

My research interest lies in theoretical and quantitative immunology, and host-pathogen interactions, particularly in the T cell interactions with virus-infected and tumour cells.

Hobbies: I like to read, bike, hike, and travel in my free time.

QuanTI research project

T cell trafficking to tumours and their interactions with tumour cells.

My current research focuses on developing mathematical models to quantify the T cell trafficking to the tumour sites and their interactions with tumour cells.

Some tumours (e.g, melanoma) supress and evade cytotoxic T lymphocytes by expressing PD-L on their cell surface. We are interested in the antibody therapies targeting programmed cell death ligands (PD-L). Our goal is to determine the antibody doses required to control/eliminate tumours. For this purpose, we will develop mechanistic mathematical models and apply them to analyse the published experimental data. These models will help to identify the determinants of successful tumour regression and to design a rational intervention.

Supervisors

Dr. Michael Block and Dr. Christoph Niederalt, Systems Pharmacology ONC (BTS-TD-ET-SPO), Bayer Technology Services GmbH

Publications

Gadhamsetty S, Beltman JB, de Boer RJ, (2015) What do mathematical models tell us about killing rates during HIV-1 infection? Immunol Lett. Nov;168(1):1-6.

Gadhamsetty S, Marée AFM, Beltman JB, de Boer RJ, (2014) A General Functional Response of Cytotoxic T Lymphocyte-Mediated Killing of Target Cells. Biophys J. Apr;106(8):1780-91.

 

 




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Funded by the EU
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Associated partners
Universidade de Vigo

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Last update: 11 June 2017