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Domonkos Varga

Domonkos Varga

Early Stage Researcher / PhD student

Charité - Universitaetsmedizin Berlin
Deutsche Rheuma-Forschungszentrum
Charitéplatz 1
10117 Berlin, GERMANY

January 2014 - January 2017


Short biography

Domonkos completed his BSc studies in Biology at Eötvös Loránd University, Budapest, Hungary (2011) and acquired his MSc degree in Biomedical Sciences (Infection and Immunity track) from the University of Amsterdam, The Netherlands (2013). He worked as an intern on human T-cell differentiation at the Department of Cell Biology and Histology of the Academic Medical Center, Amsterdam, The Netherlands (2013). In the QuanTI Network he is working on plasticity of cytokine memory in T helper cells.
His hobbies include: swimming, skiing, playing board games, reading.

QuanTI Research project

Cytokine memory in T cells
We are interested in the functional plasticity of CD4+ T-helper cells and in how the different intrinsic regulatory modules promote or suppress the transcriptional program of Th1, Th2, Th17 or Treg cell lineages. Importantly, hybrid phenotypes (Th17/Treg, Th1/2) have been described which either could be achieved by reprogramming of the different subsets (Hegazy et al. 2010) or by direct differentiation from naive Th cells (Peine et al. 2013). Until now, very little is known about the molecular mechanisms involved in the induction and maintenance of hybrid phenotypes. We seek to identify new members of these dynamic regulatory modules and to describe their cross-talk mechanisms. This would reveal how subset-specific transcriptional programs are induced and maintained.
Furthermore, we aim to reveal the molecular mechanisms behind the probabilistic production of signature cytokines in the different T cell subsets and to explore and explain quantitative cytokine memory of these important immune cells. Such knowledge will help us to create quantitative models for T cell differentiation and cytokine production, which eventually could potentiate the development of non-invasive, personalized therapies for chronic inflammatory and autoimmune diseases.

Supervisors

Professor Dr. rer. nat. Max Löhning

 

 




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Funded by the EU
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Associated partners
Universidade de Vigo

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Last update: 11 June 2017